Peptide Therapy, Weight-Loss with Results!
How about a sensible weight loss approach for 2023? Naturally occurring amino acids make proteins which are the building blocks of every cell, tissue, and organ. Peptides are small chain amino acids. Because peptides are naturally occurring, just like vitamins and supplements, not all Peptides are FDA approved. If you are seriously ready for weight loss and you mildly or moderately exercise, drink enough water, then reread the benefits of intermittent dieting and come in for an individualized weight loss consultation. We estimate >10% weight loss. Losing 5-10% of body weight is associated with a reduced risk of cardiovascular disease in overweight adults.
The body uses some peptides to improve several very precise functions that offer tremendous health benefits. Let’s talk about THREE Peptides utilized in our weight loss 3–6 month programs.
Semaglutide was FDA approved on June 04, 2021, for chronic weight management. Glucagon-like peptide-1 (GLP-1) receptor agonist. Increases secretion of insulin and inhibits glucagon by the pancreas, thereby improving glucose metabolism. Regulates regions in the brain responsible for hunger and delays gastric emptying, leading to improved control of eating, reduced cravings and suppressed appetite. If you have a BMI ≥27 kg/m2 with one weight related ailment or BMI ≥30 kg/m2 you may be a candidate. Studies showed on average 12.5% weight loss, ranging from 5% to ≥20% over 3-6 months.
CJC-1295/Ipamorelin are peptides which promote growth hormone secretion. The combination of 2 peptides boosts natural production of growth hormones (GH). CJC-1295 acts on the pituitary gland to stimulate secretion of GH. Ipamorelin blocks somatostatin and increases GH secretion. Several benefits of GH include improved ability to burn fat, weight loss and increase muscle mass.
MOTS-c is a Mitochondrial peptide. This peptide has distinct biological activities and targets the skeletal muscle and enhances glucose metabolism with improved energy. MOTS-c mitochondrialsignaling mechanism regulates metabolism within and between cells, this has implications in regulation of obesity, diabetes, exercise, and longevity.
It’s very important to consult a trained professional, like Dr. Mary Van at ThriveX™, to not only evaluate if you are a candidate for INDIVIDUALIZED weight loss peptide therapy but also to monitor your progress. The criteria for peptide therapy is based on age, medications, health issues and a discussion of peptide mechanism of action, laboratory baselines, safety, and documented benefits.
1. Ghusn,W et al. Weight loss outcomes associated with Semaglutide treatment for patients with overweight or obesity. JAMA Network Open.2022;5(9):e2231982.
2. US FOOD and Drug Administration. FDA approves new drug treatment for chronic weight management, first since 2014. June4, 2021.Accessed May2, 2022
3. Tcichman,SL et.al Prolonged Stimulation of GH and IGF-1 secretion of CJC-1295, A long acting GHRH in healthy adults. The Journal of Clinical Endocrinology & Metabolism, Vol 91 (3) March 2006, pg 799-805.
4. Gobburu,J et.al.(1991).PK-PD Modeling of Ipamorelin, a GH-releasing peptide in human volunteers. Pharmaceutical research.16.1412-6UPDATED 11.02.2022
5. Lee, C. et al. (2015) The Mitochondrial-derived peptide MOTS-c Promotes Metabolic Homeostasis and reduces obesity and insulin resistance. Cell Metabolism.21.443-454.
6. Reynolds, JC et.al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature communications (2021)12,470
UPDATED 11.02.2022
7. Lee, C et al. (2016) MOTS-c A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med. 2016 November;100:182-187